Principal Scientist, Translational - Biology
Company: Bristol-Myers Squibb
Location: San Diego
Posted on: October 23, 2024
Job Description:
Principal Scientist, Translational - BiologyApplyLocations: San
Diego - CA - USTime Type: Full timePosted On: Posted 2 Days AgoJob
Requisition ID: R1586166Working with UsChallenging. Meaningful.
Life-changing. Those aren't words that are usually associated with
a job. But working at Bristol Myers Squibb is anything but usual.
Here, uniquely interesting work happens every day, in every
department. From optimizing a production line to the latest
breakthroughs in cell therapy, this is work that transforms the
lives of patients, and the careers of those who do it. You'll get
the chance to grow and thrive through opportunities uncommon in
scale and scope, alongside high-achieving teams rich in diversity.
Take your career farther than you thought possible.Bristol Myers
Squibb recognizes the importance of balance and flexibility in our
work environment. We offer a wide variety of competitive benefits,
services and programs that provide our employees with the resources
to pursue their goals, both at work and in their personal
lives.RayzeBio, a Bristol Myers Squibb company, is a dynamic
biotechnology company headquartered in San Diego, CA. The company
is focused on improving survival of people with cancer by
harnessing the power of targeted radioisotopes. RayzeBio is
developing innovative drugs against targets of solid tumors. Led by
a successful and experienced entrepreneurial team, RayzeBio aims to
be the global leader in radiopharmaceuticals.As a translational
scientist you will be at the forefront of bridging laboratory
research with clinical applications to advance novel
Radiopharmaceutical Oncology therapies. You will play a crucial
role in supporting project teams by leveraging your expertise in
translational oncology research. Your role will involve translating
scientific findings into actionable insights that inform clinical
development strategies, identify biomarkers, and drive therapeutic
innovations. Your responsibilities will encompass a range of
activities from target validation through to clinical development
strategy, with a focus on identifying indications, understanding
resistance mechanisms, and developing rational combinations. The
ideal candidate will be an experienced, accomplished translational
scientist with outstanding interpersonal and communication skills.
The position will require an ability to work effectively in
interdisciplinary team settings. In addition to being a thought
leader, this role is expected to provide technical leadership in
the lab. The role requires an ability and willingness to work with
radioactive isotopes.*This is an onsite position located at
Rayzebio's San Diego, CA officeKey Responsibilities:
- Conduct immunohistochemistry (IHC) analysis to evaluate new
targets identified by the project teams. Interpret and present IHC
data to guide decision-making on target selection and
validation.
- Utilize molecular and genetic tools to identify and validate
anchor indications for novel therapies. Analyze clinical and
preclinical data to support the selection of lead indications.
- In partnership with a cross functional team leader, provide
strategic and operational translational leadership for project
teams on specific targets.
- Contribute to the development of translational research
strategies aligned with therapeutic goals.
- Lead efforts to develop and execute strategies for generating
data in relevant models, discover and validate biomarkers that
predict patient response to therapies, to inform clinical trial
designs.
- Develop/optimize and utilize preclinical in vivo models that
mimic human cancer biology to evaluate drug efficacy, mechanism of
action, and resistance mechanisms.
- Integrate biomarker findings into clinical development plans
and regulatory submissions.
- Investigate mechanisms of radiosensitivity and develop tools
and models to predict response to radiotherapy and identify
potential biomarkers.
- Investigate resistance mechanisms and propose strategies to
overcome resistance through rational combinations.
- Author/review study reports and regulatory documentation,
scientific presentations and publications and manage external
research collaborations.Education & Experience:
- PhD in cancer biology, molecular/cell biology, pharmacology, or
a related field and a deep understanding of cancer biology and
experience working in oncology drug development.
- 5+ years of translational oncology experience in
pharmaceutical/biotech R&D environments demonstrating
successful accomplishments and progressive leadership and
broadening responsibilities.
- Experience in working on targeted cancer therapy modalities
such as RPTs, ADCs, PDCs is highly desirable.Skills:
- Understanding of translational research principles and the
ability to apply basic research findings to clinical settings.
- Familiarity with clinical trial design, patient stratification,
and biomarker discovery/validation in the context of disease
mechanisms and therapeutic interventions.
- Proficiency in data analysis techniques, including statistical
methods, bioinformatics, and interpretation of large datasets
(e.g., genomics, proteomics).
- Ability to design and execute experiments, including
preclinical model development (e.g., cell lines, animal models,
patient-derived models), to investigate disease mechanisms and
evaluate therapeutic interventions.
- Experience in managing research projects, coordinating
timelines, and prioritizing tasks to achieve project goals
effectively.
- Understanding of regulatory requirements and guidelines
relevant to translational research, clinical trials, and drug
development processes.
- Creativity and adaptability to explore new research
methodologies, technologies, and approaches that enhance
translational research outcomes.
- Ability to work collaboratively with clinicians, researchers,
bioinformaticians, and other stakeholders to integrate diverse
perspectives and advance translational research goals.
- Excellent written and oral communication and presentation
skills and ability to work in a fast-paced, dynamic, and
collaborative environment.
- Strong interpersonal, organizational and communication
skills.
- Prior experience as a project leader or functional leader on
interdisciplinary team is critical.
- Ability to work with radioisotopes with strict adherence to
radiation safety protocols.
- Ability to successfully establish and manage external
collaborations including CROs and academic and industrial
partnerships.#RayzebioThe starting compensation for this job is a
range from $141,034-$190,811, plus incentive cash and stock
opportunities (based on eligibility). The starting pay rate takes
into account characteristics of the job, such as required skills
and where the job is performed. Final, individual compensation will
be decided based on demonstrated experience.If you come across a
role that intrigues you but doesn't perfectly line up with your
resume, we encourage you to apply anyway. You could be one step
away from work that will transform your life and career.Uniquely
Interesting Work, Life-changing CareersWith a single vision as
inspiring as "Transforming patients' lives through science", every
BMS employee plays an integral role in work that goes far beyond
ordinary. Each of us is empowered to apply our individual talents
and unique perspectives in an inclusive culture, promoting
diversity in clinical trials, while our shared values of passion,
innovation, urgency, accountability, inclusion and integrity bring
out the highest potential of each of our colleagues.On-site
ProtocolBMS has a diverse occupancy structure that determines where
an employee is required to conduct their work. This structure
includes site-essential, site-by-design, field-based and
remote-by-design jobs. The occupancy type that you are assigned is
determined by the nature and responsibilities of your role.
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Keywords: Bristol-Myers Squibb, Placentia , Principal Scientist, Translational - Biology, Other , San Diego, California
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